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PIONEER 1 compared oral semaglutide with placebo [76], while PIONEER 24 compared oral semaglutide with the SGLT2i empagliflozin (25 mg once daily), the DPP-4 inhibitor sitagliptin (100 mg once daily), and the subcutaneous GLP-1RA liraglutide (1.8 mg once daily) [38, 39, 61, 62]
Who May Benefit
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Was more than one animal strain tested
If you take PPIs (proton pump inhibitors), metformin, NSAIDs, or other medications that affect gut pH, motility, or the microbiome, adding Pendulum may produce unpredictable results
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