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Bioavailability: NAC has an oral bioavailability of approximately 6-10% due to extensive first-pass metabolism, but the deacetylated cysteine that reaches tissues effectively drives glutathione synthesis [9]
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doi: 10.1111/j.1600-0447.1992.tb10319.x 50 AlvarezBDMoralesCAAmodeoDA
For example, polymer structures consisting of liposomal DOX have received clinical approval for intracranial treatment of resectable GBM [112]
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