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Combination therapy didnt clearly add benefit over either treatment alone
Extracts from Decalepis hamiltonii delayed early onset of PD symptoms, improved circadian rhythm and motor activity in PD model flies possessing A30P and A53T -synuclein mutation which are known to cause accelerated age dependent deterioration of circadian rhythm 29
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COP1 contains four distinct domains: an N-terminal Glycine/Serine (G/S) rich domain, a RING domain which interacts with E2 ubiquitin-conjugating enzymes
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