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Fatigue is sometimes reported during the first two weeks at this dose, though it is difficult to determine whether this is a direct effect of the medication or a consequence of significantly reduced caloric intake
But peptides remain difficult to deliver across oral mucosa
A patient sat across from me last year six weeks into semaglutide, finally feeling her appetite shift for the first time in years and asked me something I hear in almost every follow-up: "Do I still have to watch what I eat, or does the medication handle that now?" It's a fair question
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