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Caloric restriction alone often fails because insulin dysfunction prevents efficient fat mobilization

Until the data of the SURPASS-CVOT trial are available, tirzepatide will most likely have a place in the algorithm of T2D therapy for patients with obesity and T2D that have the therapeutic aim to normalize glycemia and decrease body weight

Ozempic is FDA-approved for type 2 diabetes treatment but may be prescribed off-label for weight loss at a provider's discretion and professional judgement

Initial research suggested that the memory-enhancing effects often attributed to AngII were, in fact, mediated by its conversion to AngIV, acting at the AT4 receptor subtype