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The concept of microdosing reportedly dates back to the 90s, when it was part of clinical drug development, before it was adopted by psychedelics users (and then GLP-1 users)
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As with all medications in the GLP-1 receptor agonist class, retatrutide is associated with a range of gastrointestinal side effects , which were the most commonly reported adverse events in Phase 2 trials
Sources & references New England Journal of Medicine Triple-Hormone-Receptor Agonist Retatrutide for Obesity - A Phase 2 Trial Jastreboff AM, Kaplan LM, Fras JP, et al
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