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The peptide enters intestinal epithelial cells via the PepT1 transporter and directly inhibits inflammatory signaling pathways inside the cell, including NF-kB
The side effects of both medications are typically mild and resolve within a few weeks of starting treatment
Furthermore, the lower systemic levels of bile salts prompt the liver to produce more bile, which in turn feeds more TGR5 agonism into the colon (343)
Clinical trials are testing for these effects, with early results indicating better blood sugar control and the potential to reduce the need for other diabetes drugs
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