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no published trial has tested the two compounds together as a fixed combination
Although bortezomib and carfilzomib show excellent efficacy in multiple myeloma, both have to be administered systemically, therefore improving oral bioavailability will be a major goal in the development of next generation proteasome inhibitors 80
The mechanism involves upregulation of growth hormone receptors in tendon fibroblasts and increased collagen synthesis at the repair site
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