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Unlike injections, the nasal spray is painless and needle-free, making it a more comfortable option for many patients

[1] [3] According to the UK SmPC, dosing starts at 2.5 mg once weekly for 4 weeks, then increases in 2.5 mg increments every 4 weeks until the target dose (5 mg, 7.5 mg, 10 mg, 12.5 mg or 15 mg) is reached, based on individual response and tolerability

Biologic agents targeting specific inflammatory pathwaysincluding TNF- inhibitors (adalimumab, etanercept), IL-6 inhibitors (tocilizumab), T-cell costimulation modulators (abatacept), and B-cell depleting agents (rituximab)provide additional options for patients with inadequate response to conventional therapy

For skin whitening, many users opt for 500 mg to see more noticeable results