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Despite the improvement in GH/IGF-1 levels (GH 10.6 ng/mL, IGF-1 462 ng/mL), her glycemic control drastically deteriorated for 4 months (Hb1Ac 8.212.0%)

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During treatment, patients are typically monitored for symptom progression, weight changes, side effects, and overall health response

A large overlap in neuronal activity patterns was observed between the two treatments and, in agreement with previous research 37 , strong signals were detected in the arcuate nucleus, in the central amygdala and in subregions of the brainstem, including the area postrema, the nucleus of the solitary tract and the dorsal motor nucleus of the vagus nerve (Fig