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Measurement of plasma and intracellular S-adenosylmethionine and S-adenosylhomocysteine utilizing coulemetric electrochemical detection: alteration with plasma homocysteine and pyridoxal 5-phosphate concentrations

In more severe cases, surgery followed by months of physiotherapy may represent the most appropriate course of treatment

Safety across the full program was consistently favorable: adverse events, primarily mild headache and gastrointestinal symptoms, occurred at rates comparable to placebo, with no treatment-related discontinuations, no IGF-1 elevation, and no impact on glucose metabolism

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