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What they found: Oral AOD-9604 reduced body fat by 18 to 22 % vs placebo, comparable to injection administration No changes in total body weight (because lean mass rose slightly) Decrease in plasma triglycerides by 30 % Decrease in resting free fatty acids (paradoxically, mobilization of fat from depots into oxidation) No GI side effects Why it matters: It suggested that AOD-9604 could work orally , a rare property for a peptide
If you have a temporary deficiency or increased requirement (say, after a surgery or during recovery from an acute illness), you might only need a short course, perhaps a few weeks of injections, until your vitamin levels normalize or you can meet your needs by mouth again
Ongoing follow-up appointments allow providers to review progress, answer questions, and make adjustments when clinically appropriate
NNMT Selectivity Appetite Change Powder Stability 5-Amino-1MQ shows high selectivity for NNMT over other methyltransferases, reducing off-target effects
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