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This meta-analysis mainly included the SUSTAIN program, which involved weekly subcutaneous injections of semaglutide, and the PIONEER program, which involved daily oral administration of semaglutide
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The information we have comes primarily from accidental pregnancies during clinical trialsnot from deliberately designed pregnancy safety studies
However, case reports and procedural observations have described retained gastric contents in some GLP-1 users despite adherence to fasting instructions, raising concern that selected patients may present functionally as having a full stomach. This concern led to an initial conservative response
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