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De tels sels peuvent tre prpars selon des procds traditionnels, par exemple par mlange de la L-carnitine avec la L-lysine sous forme de chlorhydrate dans de l'eau et cristallisation du sel rsultant par addition d'un solvant polaire organique non miscible dans l'eau.Such salts can be prepared according to traditional methods, for example by mixing L-carnitine with L-lysine in the form of hydrochloride in water and crystallization of the resulting salt by addition of an organic polar solvent immiscible in the water
283,284,285 PEG modification can inhibit the binding of apolipoprotein E to LNPs, a key mechanism for LNP uptake by the liver, thereby affecting liver uptake of LNPs
Furthermore, they can be further modified using polyethylene glycol (PEG) in order to boost their stability
The difficult part is balance
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