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Key takeaways: Homocysteine is produced from methionine in the methionine cycle and can either be remethylated back to methionine or converted through the transsulfuration pathway into cysteine and glutathione

This enhanced cellular uptake may result in more pronounced antioxidant and detoxification effects compared to regular glutathione supplements

Without a fully functioning PPP, intraplaque cellular death is likely increased and the ensuing atheroprotective process of efferocytosis may be dysfunctional

However, it is unclear exactly which isoform acts in cardiomyocytes and how it exerts its anti-ferroptosis effect, which requires further study