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By mimicking the growth hormone-releasing peptide fragment, it can promote fat breakdown and inhibit fat accumulation, and has potential anti-tumor effects at the same time
The BW^0.8 exponent is consistent with retatrutides own matched-dose arm pairs in Rosenstock 2023 4 mg ID2 at 108.3 kg vs 4 mg ID4 at 93.1 kg (predicted Cav,ss ratio 1.13, observed 1.18, 4.6% error), and 8 mg slow at 98.4 kg vs 8 mg fast at 95.9 kg (predicted 1.02, observed 1.04, 1.5% error)
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The oral activity seen in rodents cannot be directly mapped to human oral dosing without pharmacokinetic bridging studies, which do not exist for BPC-157
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