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Unlike GLP-1 agonists, which primarily act by delaying gastric emptying and enhancing insulin secretion, BRP operates via the following mechanisms: Hypothalamic activation : BRP triggers the expression of the FOS gene, a key marker of neuronal activation associated with appetite suppression, in the hypothalamus
has served as a consultant for Novo Nordisk and Viking Therapeutics, and serves as a national lead investigator or on the executive committee for trials conducted by AstraZeneca and Novo Nordisk
Most patients lose between 2 and 5 pounds in the first month on Rybelsus, with results building gradually as the dose steps up from 3 mg to 7 mg and eventually 14 mg
Pekala et al
