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The glucagon component provides hepatic fat oxidation, thermogenesis, and increased energy expenditure -- metabolic effects absent from GIP/GLP-1 approaches
In SURMOUNT-1, around 4 to 7% of people on tirzepatide stopped the medication because of side effects, compared with 2.6% on placebo
pluricaulis also has been found to ameliorate tau induced neurotoxicity in Alzheimers disease 54
It's a foundational fix, not a surface-level treatment
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