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In contrast, another placebo-controlled trial found that a daily B-vitamin regimen that led to significant homocysteine lowering in high-risk elderly individuals could limit the progressive atrophy of gray matter brain regions associated with the Alzheimers disease process (70)
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Bariatric surgery already produces significant changes in gut hormone secretion, including endogenous GLP-1 elevation, which raises important questions about the incremental benefit of exogenous GLP-1 agonists in this altered physiological state
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