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Tirzepatide is an approved medicine
For context, the concentrations required to activate intracellular cascades such as PI3K/Akt, upregulate BDNF, or stimulate autophagy in neuronal tissue are derived from preclinical studies that used substantially higher relative exposures than those achievable in the human brain at therapeutic doses
Singh et al., 2008
case reports document serious systemic toxicity and rhabdomyolysis at mega-doses (6 mg) [4]
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