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And thats why GLP-1s are very confusing, but if you want a patient to be successful on them, you want to make sure youve got the lifestyle, you got the right expectations, you know what the entry point is, what the duration is, and more importantly, what happens when they hit a weight and quote unquote, what is the endpoint of GLP-1s

Altogether, muscle loss during GLP1RAs therapy is multifactorial, involving reduced protein intake and negative energy balance, hormonal adaptations, impaired mTOR signaling and protein synthesis, increased proteolysis and potential mitochondrial adaptations, and age, frailty, and physical inactivity as modifiers (Fig

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