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If you experience significant gastrointestinal adverse effects, your doctor may recommend pausing or reducing the dose
International expert consensus published in Obesity Pillars (Sievenpiper et al., 2025) recommends prioritizing protein to preserve muscle mass during rapid weight loss, alongside careful attention to fiber, hydration, and micronutrients
Staying at a dose that is producing consistent results with manageable side effects is clinically appropriate
Available at: Last updated: 3/4/2015b
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