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Study selection RCTs comparing any drug with placebo, reporting OH as an adverse effect or outcome in adults (18 years), were included
The liver stores B12, and these stores can last a significant time (up to several years for non-deficient individuals), but when they are depleted, it takes consistent input to rebuild and maintain them
Future studies are expected to elucidate the safety and efficacy of 5-amino-1MQ, identifying specific populations that may benefit or experience adverse effects
Public health should never be guided by ideology over evidence
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