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What in the world does not expire at some point

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This excessive connectivity leads to chronic mitochondrial Ca 2+ overload, triggering reactive oxygen species (ROS) production and hepatic UPR activation ( Notably, current pharmacological strategies for metabolic disorders have identified the normalization of MERCS connectivity as a pivotal therapeutic target (Yang et al., 2021)

Theres even an upcoming phase 2 trial that will study whether GLP-1s affect depressive symptoms in people with major depressive disorder