The authors administered oral Dihexa to APP/PS1 transgenic mice (a standard amyloidopathy model of Alzheimers disease) and showed that brain AngIV levels were elevated relative to wild-type after Dihexa administration, that spatial learning and memory were restored on Morris water maze testing, that hippocampal neuronal density and synaptophysin protein expression were preserved, that astrocyte and microglial activation were reduced, and that pro-inflammatory cytokines (IL-1, TNF-) decreased while anti-inflammatory IL-10 increased
Vaginal Rings: These rings release hormones directly into the vaginal tissue, offering a convenient and long-lasting option for addressing vaginal atrophy
The 2mg/mL concentration (5mL bacteriostatic water) provides the best balance of concentration, stability, and dosing precision
The most common side effects are gastrointestinal, including nausea (occurring in 20-30% of patients), diarrhea, vomiting, constipation, and abdominal discomfort