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Vitamin B12, supplied via food or oral supplements, can be absorbed by the body in two different ways (4): Through the transport protein called intrinsic factor in the small intestine Through passive diffusion in the mucosa membranes of the mouth and small intestine The maximum absorption ability through the intrinsic factor is somewhere between 1.5 2 g per meal
Yang et al., 2024)
Patients on this protocol who also use metabolic support agents like Metformin should note that both agents activate AMPK, and physician oversight is warranted to avoid compounding effects on blood glucose that could theoretically cause hypoglycemia in susceptible individuals, though this has not been reported clinically with MOTS-c at standard doses
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