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In all the three structures, the densities of most ECL1 residues are invisible, whereas ECL2 and ECL3 are well-defined in the EM maps of GLP-1R and GIPR, and largely solved in GCGR except one short segment (D299G302) (Supplementary Fig

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In 3Tg-AD treated with DA-JC4, the ability of recognize new object and spatial working memory was improved, hippocampal A and tau pathology were alleviated, and hippocampal synaptic plasticity also was improved as well as levels of PSD95 and SYP were increased (235)