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The effect took longer to manifest than hydroquinone (visible at 812 weeks vs 46 weeks), but rebound hyperpigmentation was significantly lower: only 9% of glutathione users experienced pigment return at 12 weeks post-treatment vs 38% with hydroquinone
Dosing Framework by Clinical Context and Biomarker Status Glutathione dosing should account for baseline oxidative stress, antioxidant capacity, and individual metabolic factors
Chronic low-grade inflammation also damages L-cells directly, further reducing GLP-1 output
new recommendations to minimise risk
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