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Hepatology 1996
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Subsequently, E3 ligases either behave as bona fide enzymes (HECT E3s), or a matchmaker (RING E3s), to transfer ubiquitin from a charged E2 to substrates, facilitating the formation of an isopeptide bond between the C terminal glycine of ubiquitin and substrate lysine residue 1 (Figure 1)
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