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The researchers found that allulose: Stimulated GLP-1 secretion from intestinal cells Activated beneficial metabolic pathways Improved glucose tolerance Demonstrated chronotherapeutic effects on metabolism Additional research published in Nutrients (2022) showed that allulose works synergistically with GLP-1, activating specific neurons in the brain's appetite control centers, leading to reduced food intake in test subjects

The binding affinity of CB-03-01 is much lower than RU58841 though and it is very cost prohibitive, so for the time being, that strategy is likely not viable for most

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