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2007: A small, multicenter clinical study among 56 people with neuropathy associated with antiretroviral drug therapy showed that receiving 500 mg of acetyl-L-carnitine twice daily intramuscularly for two weeks, followed by 1,000 mg twice daily orally for 6 weeks, reduced pain by 0.89 points (on a 010 scale) compared to placebo

Given that prenatal adversities frequently occur in combination or across different substance exposures in human population, examining whether distinct developmental insults engage overlapping molecular adaptations may help identify shared substrates of neurodevelopmental vulnerability [79, 80, 81]

Lucy, M

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