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Controlled freezing studies of recombinant hGH demonstrated that insoluble particulate aggregation increases sharply with cooling rate, with pH 7.4 formulations producing markedly more light-scattering particulates than pH 7.8 formulations after freeze-thaw (Eckhardt, Oeswein & Bewley, 1991)

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When the platelet count is very low, the risk of bleeding is has very low platelets has a high risk of bleeding currently has a bleed because of a lack of platelets This treatment replaces the lost platelets by giving someone either whole blood from a donor or just a transfusion of platelets alone

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