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Predominantly located in the ganglion cell layer of the retina with additional sparse expression detected in the inner nuclear layer and outer nuclear layer, GLP-1R was found to be expressed at high levels in the retina, even surpassing in tissues like the liver and bowel
Note: Location counts are approximate
The cardiovascular outcomes trials that enrolled tens of thousands of patients with type 2 diabetesincluding LEADER (liraglutide), SUSTAIN-6 (semaglutide), REWIND (dulaglutide), and EXSCEL (exenatide ER)found no significant increase in overall cancer incidence compared to placebo over follow-up periods ranging from approximately two to five years
S.ChaoM
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