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For rectal use only

Fatigue From Disease and Aging Fatigue is common in cancer patients after treatments from chemotherapy, radiation therapy, and poor nutrition

The published data regarding agonist-induced internalization of GIPR are just as conflicting as, if not more so than, that for GLP-1R

Safety Profile The most common adverse events documented across retatrutide results data were gastrointestinal in nature, with incidence increasing at higher doses: Nausea: 6-31% (dose-dependent), primarily during escalation periods Diarrhea: 6-25%, generally mild to moderate Vomiting: 0-16%, occurring mainly in the first weeks of each dose increase Decreased appetite: 3-19%, which contributed to the weight reduction effect Constipation: 3-12%, consistent with GLP-1 receptor-mediated gastric slowing Serious adverse events were rare across all cohorts