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To much production of oxidants results into oxidative damage to cells and matrix molecules in the gingival tissues, like lipid peroxidation, protein oxidation, and DNA damage, aggravating the severity and duration of the inflammatory response (Chapple and Matthews, 2000)

Available at: Accessed 7/18/2012

Early diagnosis of anemia in the early 1800s were based solely on physical examinations such as fatigue, paleness, sweating, difficulty breathing, and dizziness