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One of the key limitations of the selected studies lies in the inherent complexity of psychiatric disorders, which are characterized by unknown etiologies and considerable heterogeneity
As a central component of the cell-to-cell and intracellular lactate shuttles, lactate ensures efficient energy distribution from its production sites such as glycolytic muscle fibers to oxidative tissues, including heart, brain, and oxidative muscle fibers, where it serves as a primary fuel for mitochondrial oxidative phosphorylation [233, 234]
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