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The animals were group-housed until one week before treatment initiation, after which they were given daily subcutaneous injections of vehicle or Cagrilintide at doses of 0.3, 3, or 30 nmol/kg for 21 days

Call 999 or go to A&E immediately if you experience: Severe allergic reactions, including facial swelling, difficulty breathing, or severe itching Chest pain or fainting episodes Severe abdominal pain with persistent vomiting Contact your GP or NHS 111 urgently if you experience: Severe or persistent vomiting or diarrhoea lasting more than 24 hours, as this increases dehydration risk and may prevent adequate medication absorption Diarrhoea containing blood or mucus , particularly if accompanied by fever or severe abdominal cramping, as this could indicate C

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These dual-tagged vectors enable purification of HaloTag fusion proteins that still retain the covalent coupling ability of the HaloTag protein