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While an overdose of APAP yields peak serum concentrations (10 20 g/mL) within 4 hours, a patient taking the medication safely will achieve peak concentrations within 1.5 hours, with a half-life of 1.5 3 hours
10.3390/ijms241411691 61
This can create a paradoxical effect, where the individual feels less drunk due to the stimulating effects of caffeine but is actually more impaired
[1] In living cells, glutathione disulfide is reduced into two molecules of glutathione with reducing equivalents from the coenzyme NADPH
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