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GLP-1 and GIP receptors are expressed in regions including the hypothalamus, hindbrain, and area postrema, and tirzepatide is used as a tool compound to probe how dual receptor engagement modulates neuronal firing, appetite-related gene expression, and neuroinflammation markers in cell and organoid systems
Because cholesterol and triglyceride levels are tied closely to weight, metabolism, and how your body manages fats, medications like GLP-1 may have side benefits beyond just weight or glucose control
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ADVERSE EFFECTS In the cagrilintide, single-agent study between 2% and 6% (26%) of participants in the cagrilintide groups discontinued treatment prematurely because of adverse events, compared with 7% (7%) of participants in the liraglutide 3.0 mg group and 3% (3%) in the pooled placebo group
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