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95% CI, 0.82-0.94), heart failure hospitalization by 11% (HR = 0.89

For context, newer agents like mazdutide and survodutide are being studied for similar gallbladder effects, though data remains limited

It is central to it

These results suggest chronic treatment with GLP-1R agonists could lead to proliferation/chronic activation of PSCs, which may lead to important effects in the pancreas