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[78] found that Lira inhibited proprotein convertase subtilisin/kexin type 9 (PCSK9) expression in HepG2 cells and db/db mice through hepatocyte nuclear factor 1 (HNF1)-dependent mechanism, and may inhibit LDLR expression in db/db mice through PCSK9 independent pathway, and ultimately reduce liver cholesterol accumulation
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When pooling the results of COBRIT with those of 10 other clinical trials in a meta-analysis, citicoline treatment for acute-phase TBI was linked to a higher degree of independence, i.e., the capability of performing daily activities without needing assistance (104)
Geller, L
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