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And the Department of Managed Health Care as well as Covered California California and other payers have stated that the recent popularity of high-priced brand-name weight loss drugs and diabetes medications drove much of the increase in the total prescription drug spending for Health Plans in 2022 and 2023

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doi: 10.2337/dc19-2419 10 ItoYAmbeKKobayashiMTohkinM

[29, 30, 31] Risk factors: Diabetes (especially in combination with SGLT2 inhibitors use) Reduced oral intake and severe GI symptoms Dehydration Presentation: Nausea, vomiting, abdominal pain Anion gap metabolic acidosis Elevated ketones Normal or mildly elevated glucose Key point: EDKA has not been observed in non-diabetic patients in large cohort data