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This is one of the most significant gaps in clinical care, she says

Measuring Estrogen before addressing suspected hormone imbalances and monitoring estrogen levels during hormone replacement therapy are crucial in maintaining hormone balance, but the clinical science behind the risks and benefits of Estrogen relating to cancer remained a mystery until estrogen metabolism became more understood

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Whether combining these specific compounds produces additive or synergistic effects has not been formally studied, but the non-overlapping mechanisms provide a theoretical rationale