semaglutide sequence Mechanism of Action SEMAGLUTIDE drug of choice dm_091926.pptx

Irregular dosing can mask your true response to semaglutide, making it harder for your PlexusDx provider to determine whether you need a dose adjustment or a different compound

Sanders MJ, Grondin PO, Hegarty BD, Snowden MA, Carling D

Patients should be counseled to report severe abdominal pain immediately Gallbladder disease : Increased risk of cholelithiasis and cholecystitis, likely related to rapid weight loss Hypoglycemia : Risk is low when used alone but increases when combined with insulin or sulfonylureas Thyroid C-cell tumors : Based on rodent studies, these agents carry a boxed warning and are contraindicated in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 Acute kidney injury : Can occur, particularly with dehydration from gastrointestinal side effects Diabetic retinopathy complications : Semaglutide may worsen diabetic retinopathy in patients with diabetes, particularly with rapid improvement in glucose control Severe gastrointestinal disease : Use with caution in patients with gastroparesis or severe gastrointestinal disease

It plays a crucial role in glucose homeostasis by stimulating insulin secretion, suppressing glucagon release, and slowing gastric emptying