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For instance, research on Semaglutide 2.4 mg shows it can reduce calorie intake by about 35%

Scientific Research Fund of Binzhou Medical University (BY2021KYQD032), National Natural Science Foundation of China (grant number 82200981), Special Funds of Taishan Scholars Project of Shandong Province (grant number tsqn202312384), and the Natural Science Foundation of Shandong Province (grant number ZR2022QH358)

Cons of orforglipron At the highest (36mg) dose in ACHIEVE-1, 8% of trial participants discontinued usage owing to adverse events, with vomiting and nausea reported in 14% and 16% of participants respectively