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To allow extracellular polymerization in the absence of cleavable carbohydrate precursors would necessitate the secretion of large quantities of activated UDP-sugars by the bacteria
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To successfully employ an all-comers strategy moving forward, manufacturers need to ensure products have strong clinical and/or non-clinical differentiation, a robust data package that addresses a range of patient types and comorbidities, and well-funded physician and patient facing marketing campaigns
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