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It makes a lot of sense due to the difference in response and tolerance rates among people who are taking GLP-1 medications
However, the NAC monotherapy arm (600 mg three times daily) showed a trend toward slower decline in forced vital capacity (FVC) that did not reach statistical significance compared to placebo (Martinez et al., N Engl J Med, 2014) [45]
Once symptoms resolve, re-titration using a slower dose-escalation schedule may improve long-term tolerability
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