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While density for the N-terminal lipidation was not visible in the lower resolution cryo-EM map of the repeat Cagri-CTR-Gs complex ( N = 2), the outward rotamer of H296 ECL2 was observed, congruent with similar interactions between the N-terminal acylation and ECL2
In contrast, natural bioactives like apigenin and ellagic acid are derived from dietary sources (parsley, chamomile, pomegranates, berries), making them relatively accessible and affordable as nutraceuticals
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This raised the level of oxidative stress that can further lead to renal complications (Liakopoulos et al., 2017)
