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Moreover, genome-wide association studies (GWAS) across different ethnic groups have identified polymorphisms in over 70 non-HLA loci, some of which include key protein-encoding genes that have been shown to play an immune-associated function ( Figure 1 ) (56, 67, 68)

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Rosa Caballero, stated that the allergens involved in vitamin B12 reactions is likely to be a hapten, a small molecule that can trigger an immune response when it binds to a larger carrier protein