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Abstract Diabetic Kidney Disease (DKD) is the leading cause of end stage renal disease (ESRD) worldwide
Notably, body weight loss was correlated to increased abundance of Akkermansia muciniphila , a mucin-degrading SCFA-producing species which has been reported decreased in obesity and show negative correlation to markers of gut permeability and inflammation 70
KPV, the C-terminal tripeptide of -MSH (Lys-Pro-Val), has been investigated for its interaction with NF-B signaling, with researchers observing inhibition of NF-B nuclear translocation and downstream inflammatory cytokine expression (TNF-, IL-6, IL-8) in cell culture models
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